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Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria
Abstract
HIV and malaria co-infections affect iron status. The present study was designed to determine the collective predictive power of some iron markers in HIV infected and malaria co-infected participants. For this
study, 101 participants were randomly recruited from indivividuals requesting for HIV screening. The participants were grouped as ‘asymptomatic HIV participants (n=36); asymptomatic HIV-malaria co-infected participants (n=19); symptomatic HIV participants (n=16) and HIV uninfected control participants (n=30). Blood analysis were performed for HIV infection, malaria infection, haemoglobin (g/dl), CD4 + T cell count
(/mm3), albumin (g/l), iron (ug/dl), UIBC (ug/dl), TIBC (ug/dl) and percent transferrin saturation (TS%). The analysis of variance (ANOVA) showed that the blood concentrations of haemoglobin (f=4.805, p<0.01), iron (f=32.368, p<0.01), TIBC (f= 20.467, p<0.01), TS% (f=7.616, p<0.01) and albumin (f=16.150, p<0.01), were significantly different amongst the groups. The serum albumin, iron, TIBC and TS% were significantly lowered in asymptomatic HIV, asymptomatic HIV-malaria co-infected and symptomatic HIV participants compared respectively with corresponding parameter in the control participants (p<0.01). The CD4+T cell count was significantly lowered in symptomatic HIV participants compared with asymptomatic HIV participants with or without malaria co-infection (p<0.01). The study suggests that iron status may be affected
in HIV infected individuals. The implications of the result are discussed.
study, 101 participants were randomly recruited from indivividuals requesting for HIV screening. The participants were grouped as ‘asymptomatic HIV participants (n=36); asymptomatic HIV-malaria co-infected participants (n=19); symptomatic HIV participants (n=16) and HIV uninfected control participants (n=30). Blood analysis were performed for HIV infection, malaria infection, haemoglobin (g/dl), CD4 + T cell count
(/mm3), albumin (g/l), iron (ug/dl), UIBC (ug/dl), TIBC (ug/dl) and percent transferrin saturation (TS%). The analysis of variance (ANOVA) showed that the blood concentrations of haemoglobin (f=4.805, p<0.01), iron (f=32.368, p<0.01), TIBC (f= 20.467, p<0.01), TS% (f=7.616, p<0.01) and albumin (f=16.150, p<0.01), were significantly different amongst the groups. The serum albumin, iron, TIBC and TS% were significantly lowered in asymptomatic HIV, asymptomatic HIV-malaria co-infected and symptomatic HIV participants compared respectively with corresponding parameter in the control participants (p<0.01). The CD4+T cell count was significantly lowered in symptomatic HIV participants compared with asymptomatic HIV participants with or without malaria co-infection (p<0.01). The study suggests that iron status may be affected
in HIV infected individuals. The implications of the result are discussed.
