In vivo antimalarial activity of methanol leaf extract of Bombax buonopozense in mice infected with Plasmodium berghei

  • GC Akuodor
  • CC Mbah
  • UA Megwas
  • NC Ikoro
  • JL Akpan
  • BO Okwuosa
  • UA Osunkwo

Abstract

Bombax buonopozense is used in ethnomedical practice for the treatment of fever. The methanol leaf extract of this plant was evaluated for in vivo antiplasmodial activity against chloroquine sensitive plasmodium berghei in mice. The antiplasmodial effect during early and established infections was investigated. The extract (200-600 mg/kg, p.o) exhibited significant (P<0.05) antimalarial activity both in four-day early and in an established infection tests. The LD50 of the extract was established to be greater than 5000 mg/kg, p.o in mice. The result suggests that B. buonopozense leaf extract possesses significant (P< 0.05) antiplasmodial activity thus confirming its traditional use in malarial therapy.

Keywords: Bombax buonopozense; Herbal medicine; Plasmodium berghei berghei; Mice

Published
2012-05-31
Section
Articles

Journal Identifiers


eISSN: 1997-342X
print ISSN: 1991-8631