The effect of <i>Mondia Whitei</i> on the Histology of the brain of Wistar rat

Abstract

This study was designed to investigate the effect of Mondia whitei on the histology of the brain. 20 adult male Wister rats were involved in the study.The animals were assigned into four groups: a control (group A) and three test groups (B, C and D). Animal weights were measured before and after acclimatization (2 weeks); and after three weeksof dosage administration. At the end of three weeks, the animals were sacrificed to harvest the brain for histological study. The results showed that while normal brain cells were presented in the control (group A), group B presented cellular pyknosis, necrosis, degenerative vacoulations, and mild infarction without gliosis. Group C showed cellular degeneration, pyknosis, gliosis/astrocytosis, vacoulation, while group D showed cellular degeneration,  pyknosis and parenchymal erosion. The observed histological changes were duration dependent and suggest that Mondia whitei is toxic to the brain and may induce neurotoxic damages in a duration dependent manner. Hence, there is a need for further research on the effects of Mondia whitei on other organs and system.

Key words: brain, mondia whitei, neurotoxic effects, histology