PROMOTING ACCESS TO AFRICAN RESEARCH

International Journal of Medicine and Biomedical Research

Log in or Register to get access to full text downloads.

Remember me or Register



Soft versus hard nanoparticles in the delivery of aromatic macrocycles for photodynamic therapy of cancer

A Díaz-Moscoso

Abstract


Background: Photodynamic therapy is a medical strategy to treat some types of cancer. It is based on the use of a photosensitiser, usually porphyrin or phthalocyanine derivatives, to generate toxic species in the cells upon light irradiation. Aim: An overview of the different types of nanoparticles already investigated to deliver the photosensitisers until its target is given in this review. Materials and Methods: Previous literature and various scientific search engines were used for the review. Results: A classification of the nanoparticles based on the nature of their components, ‘hard’-inorganic and ‘soft’-organic, is made and several advantages and disadvantages about their uses are pointed out. Also, a comparative summary is outlined. Conclusion: There are still some drawbacks that need to be sorted out for photodynamic therapy to become a generalised cancer treatment. These could be overcome by using nanoparticles as carriers for the photosensitisers.

Keywords: Nanoparticles, photodynamic therapy, porphyrins, phthalocyanines, drug delivery, photosensitisers



http://dx.doi.org/10.14194/ijmbr.114
AJOL African Journals Online