Comparison of the sickling and gelation properties of acidic metabolites of Aloe Vera and Cajanus Cajan

  • AE Ejele

Abstract

The effects of acidic metabolites of A. vera and C. cajan extracts on the sickling and gelation times of human HbSS erythrocytes were investigated to obtain a better understanding of the anti-sickling compounds contained in them for use in the management of sickle cell disease. The results obtained showed that the acidic metabolites of A. vera extract exhibited a greater ability to revert already sickled erythrocytes to their normal morphology. The number of unsickled erythrocytes increased remarkably with metabolite concentration from 565 to 800 (x 106/ne) A. vera extract as against 127 to 380 (x 106/ne) for C. cajan. A similar trend was observed in the gelation times, which also increased with metabolite concentration. In all, the A. vera metabolite showed a complete absence of sickled erythrocytes, the highest number of unsickled erythrocytes and best gelation times at all concentrations. Therefore, it was concluded that the acidic metabolite of A. vera was a better gelation inhibitor and erythrocytes reverser. The active principle in the anti-sickling and reversal processes probably involves flavonoids, simple phenols and/or tannins.

Keywords: Aloe vera, Cajanus cajan, sickle cell disease, erythrocytes, gelation times

International Journal of Natural and Applied Sciences, 7(1): 104 - 108, 2011

Author Biography

AE Ejele
Department of Chemistry, Federal University of Technology, PMB 1526, Owerri, Nigeria
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Articles

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eISSN: 0794-4713