Anti-Sickling Potential of <em>Aloe Vea</em> Extract Iii: Gas Chromatography/Mass Spectrometry Characterization of Neutral Metabolite

Abstract

The neutral metabolite obtained from ethanol extract of Aloe vera was characterized using the Gas Chromatography/Mass Spectroscopy. The results showed that the oil contained five different compounds, which included hexadecanoic acid, ethyl ester; phytol; 2-methyloctadeca-3,13-diene-1-ol; cotadeca-9,12,15-trienoic acid, ethyl ester and 3’,8,8’–Trimethoxy-3-piperidyl-2,2’-binaphthalene-1,1’,4,4’-tetrone (“Aloverone”), whose retention times were 28.95, 31.37, 32.11, 32.23 and 39.66 minutes respectively. It was concluded that “Aloverone” could be responsible for the observed anti-sickling properties of the neutral metabolite of Aloe vera extract.

Keywords: Sickle cell disease, Aloe vera extract, neutral metabolites, “Alloverone”