A study of tracheal prostheses produced by composite laminate fabrication methodIn vitro: biodegradation and In-vivo implantation experiments
Natural tracheal may become defective due to, among other things, abnormal narrowing or fistulas, direct or indirect result of accidents or narrowing caused by inflammation. In an acute situation when direct anastomoses (cross-connection) cannot be made, tracheal prostheses are often needed to bridge the defects. This study reports in-vitro biodegradation and in-vivo implantation studies on prosthetic tracheal composite specimens fabricated by filament winding. The tracheal prostheses fabricated with biocompatible polymeric fibre and matrix materials that were either biodegradable or non-biodegradable, were used and assessed for their performance. The study revealed that the characteristics of the tracheal prostheses were controlled by the fibre volume fraction and the proportion and combination sequences of the biodegradable and non-biodegradable components of the mixed matrix. The in-vivo implantation showed fairly satisfactory results in satisfying the stringent mechanical requirements imposed by nature in natural tracheas. Although relatively short survival periodswere observed in the animals used, after eliminating mechanical design as a cause of failure, failure could be said to have occurred due mainly to insufficient tissue growth onto the prostheses.
Keywords: Trachea, Biocompatibility, Filament Winding, in-vitro Degradation, in-vivo Implantation, Block Copolymer.