Synthesis and characterization of heteroleptic metal complexes of Isoniazid and Metformin

  • O. F Akinyele
  • E. G Fakola
  • L. M Durosinmi
  • T. A Ajayeoba
  • A. O Ayeni


Mixed ligand complexes of Metformin and Isoniazid have been synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy, magnetic moments and conductivity measurements. The infrared spectra revealed the coordination of the ligands to the metal ions [manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)]. Meformin coordinated as a bidentate ligand via the imine nitrogen while isoniazid coordinated through its amino nitrogen (NH ) and carbonyl oxygen (C=O). The electronic 2 spectra and magnetic moments for the complexes strongly suggested a six coordinate octahedral geometry. The  molar conductance values of the complexes are within the range 0.45-8.72 Ω-1 cm2 mol-1 , and this confirms the non-electrolytic nature of the complexes.

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eISSN: 0794-4896