Synthesis and characterization of heteroleptic metal complexes of Isoniazid and Metformin

Abstract

Mixed ligand complexes of Metformin and Isoniazid have been synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy, magnetic moments and conductivity measurements. The infrared spectra revealed the coordination of the ligands to the metal ions [manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)]. Meformin coordinated as a bidentate ligand via the imine nitrogen while isoniazid coordinated through its amino nitrogen (NH ) and carbonyl oxygen (C=O). The electronic 2 spectra and magnetic moments for the complexes strongly suggested a six coordinate octahedral geometry. The  molar conductance values of the complexes are within the range 0.45-8.72 Ω^-1 cm² mol^-1 , and this confirms the non-electrolytic nature of the complexes.