Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of Citrus sinensis peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats

  • P.O. Osarumwense
Keywords: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.

Abstract

Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. 

Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.

Section
Articles

Journal Identifiers


eISSN: 2659-1502
print ISSN: 1119-8362