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Journal of Applied Sciences and Environmental Management

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Interleukin 10 And 18 levels in Essential Hypertensive

O.O. Odewusi, H.B. Osadolor

Abstract


The mechanism underlying a sustained blood pressure elevation and its sequelae on the inflammatory cascades have not been totally unraveled. This research was, in addition to body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP) therefore, primarily set to assess the levels of; interleukins -18 and 10 (Il-18 and Il-10) as markers of pro and anti-inflammation. The study included 317 subjects-100 untreated with essential hypertension and currently not on drugs, 114 with essential hypertension and on antihypertensive drugs together with DASH diets and lifestyle modifications. The remaining were 103 control subjects with normal blood pressure. All parameters were assessed in treated and untreated hypertensive patients relative to apparently healthy subjects. Secondarily, it was also designed to assess the effect of treatment, gender and age on all estimated parameters. The results were subjected to statistical analysis using SPSS 21. The Student’s t test was used in comparing means. Values were Significant at P<0.05. SBP, DBP, Il-18, were significantly increased while IL10 was significantly decreased in both treated and untreated hypertensive compared to control. BMI was insignificantly increased in treated hypertensive but significantly increased in untreated hypertensive relative to control. SBP, DBP, Il 18, were significantly lower while IL10 was significantly higher in treated hypertensive compared with untreated hypertensive. It was discovered that inflammation is a hallmark in hypertensive can be significantly reversed through the administration of antihypertensive drugs, diets and a strict adherence to healthy lifestyle modifications. These findings could help to design better interventions and get better outcomes for essential hypertensive.

Keywords: Essential hypertension, interleukins, Anti-inflammatory, pro-inflammatory




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