Neutral Effect of Coffee Senna (Senna occidentalis (L.) Link Leguminosae) Leaf Ethanol Extract on Reproductive Parameters in Male Wistar Rats

Abstract

Many antimalarial remedies are known for reproductive toxicity in male. Also, several plants are known to have antifertility action in both sexes. The aim of this study is to evaluate the effect of ethanol extract of Senna occidentalis (L.) Link Leguminosae leaf (EESO) on male reproductive parameters such as sperm count, motility, morphology and the histology of testes in Wistar rats by employing standard procedures. The extract (50% ethanol) was orally administered to male Wistar rats daily, at 250, 500 and 1000 mg/kg with distilled water as control, for 20 days after which reproductive parameters were performed on the epididymal sperm and testes. The results show that all features were consistent with normal histology of the testes in the treated and untreated groups, the sperm count (SC), motility (SM) and morphology (MP) were also comparable with the control. The plant has been shown to be devoid of the traditional sperm toxicity associated with antimalarial agents.