Aquaculture venture in Niger Delta Region of Nigeria is an industry that encompasses fish cultivation in a controlled environment. It has evolved through numerous phases and stages with its potential yet to be fully tapped. To affirm this potential in contributing to human development, food security and improved standard of living, the aquaculture industry requires new approaches. Hence, this paper reviews the status of fish farming in Niger Delta, its subsistence state and its inability to meet the demand for fish by the populace, thus necessitating the need for transforming aquaculture from subsistence to commercial level. The components and the systems of commercial fish farming were thoroughly discussed. Also, constraints to commercial fish farming in the region were elucidated. The strategies for promoting commercial aquaculture such as, increase in awareness of aquaculture products, subsidizing of aquaculture inputs, training and manpower development, government support, formation of fish farmers cooperative societies, access to loans and credit facilities, promotion of research activities, effective fisheries policies, good institutional framework, and reducing the levels of corruption and insecurity in the region, were clearly pointed out as a veritable tools, for transforming the present state of aquaculture in Niger Delta, through planned, focused and coordinated effective management strategies, by individual farmers, government agencies and relevant institutions for sustainable development of the region in particular and the country in general.