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International Journal of Medicine and Health Development

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A report of clinical trial conducted in Toto ointment and soap

C.O. Alebiosu, A. Ogunledun, D.S. Ogunleye

Abstract


Aim: The efficacy of Toto ointment and soap on common skin disorders was tested.

Methods: A cohort of Nigerians with common skin conditions such as fungal and bacteria skin infections, scabies, acne vulgaris and dandruff were selected and followed for a period of twelve weeks. The study is a comparative, prospective, blinded, observational study. Following a placebo run in / wash out period, patients were given either a Toto ointment, or soap or a combination of these, or sulfur ointment alone. Cure rate, adverse drug effects and acceptability of the products were assessed.

Result: Out of the 595 patients selected for the study with common skin diseases, 446 (74.9%) had fungal infections while 64 (10.8%) had scabies infections. Forty-seven (7.9%), thirty-six (6.1%) and 2 (0.3%) patients had bacterial skin infections, acne vulgaris and dandruff respectively. At the end of treatment period, 92 (71.3%) of 129 patients with fungal skin infections and 41 (87.2%) out of 47 patients with scabies were successfully treated with Toto ointment. Although few patients were seen with bacterial skin infections during the study period, the patients showed good response to the ointment, the soap or a combination of the two.
 Overall, the combination of Toto ointment and soap gave a better clinical success rate on all diseases when compared to sulfur ointment alone. The study has shown the efficacy and tolerability of Toto products (skin ointment and soap) in the management of common skin disorder.

Conclusion:Toto ointment and soap are particularly efficacious in the management of common skin conditions such as fungal and bacteria skin infections, scabies, acne vulgaris and dandruff.


Key words: Toto products, Clinical Trial, Common Dermatoses.


[Jnl College Medicine Vol 8(1) 2003: 58-62]



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