Thermodynamic Parameters of Solutions of Sildenafil Citrate in Some Organic Solvents at Different Temperatures

Abstract

The solubility of Sildenafil citrate in some organic solvents; hexane, toluene,1-butanol and 1,2 dichloroethane has been determined using gravimetric method over different temperature range (298.15 K to 328.15 K) at one atmospheric pressure. The modified Apelblat and Buchowski-Ksiazczak λh equations were used to correlate the experimental solubility data. Further, various thermodynamic parameters have been evaluated from these solubility data.

Keywords: Solubility, Organic solvents, Sildenafil citrate, Thermodynamic parameters