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Journal of Fundamental and Applied Sciences

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Thermodynamic Parameters of Solutions of Sildenafil Citrate in Some Organic Solvents at Different Temperatures

S Baluja, K Bhesaniya

Abstract


The solubility of Sildenafil citrate in some organic solvents; hexane, toluene,1-butanol and 1,2 dichloroethane has been determined using gravimetric method over different temperature range (298.15 K to 328.15 K) at one atmospheric pressure. The modified Apelblat and Buchowski-Ksiazczak λh equations were used to correlate the experimental solubility data. Further, various thermodynamic parameters have been evaluated from these solubility data.

Keywords: Solubility, Organic solvents, Sildenafil citrate, Thermodynamic parameters




http://dx.doi.org/10.4314/jfas.v6i1.9
AJOL African Journals Online