Pharmacodynamic Effects of Piperazine Citrate on the vascular smooth muscle of the rat

Abstract

Effect of piperazine citrate on the vascular smooth muscle using rat hindquarters was investigated. Piperazine caused dose-dependent increase in flow rate of 51.69 +2.59, 89.33 + 6.23 and 200. 4 + 13.12% respectively for doses 25 and 10ìg over the control values indicating vasodilatation. Compared to the value from control animals (2.36 + 0.57%) these values were statistically significant using student’s ”t” test (p<0.0001). At peak activity, adrenaline 2ìg caused an average fall in flow rate of 49.0 + 3.02% indicating vasoconstriction. Various doses of piperazine citrate antagonized this effect. The average % increases in flow rate due to the intervention with piperazine 2ìg and 5ìg were 32.02 + 2.99 and 61.1 + 3.63 respectively. The average flow rates (ml/5min) caused by adrenaline 2ìg before piperazine 2 and 5ìg were added were 2.2 +0.46 and 2.48 +0.21 respectively. Piperazine 5ìg induced a statistically significant increase in flow rate 10 minutes later to 4.0 + 0.36 ml/5min (p=0.0064). The average increase produced by piperazine 2ìg was, however, not statistically significant (p=0.3673)