Journal of Medical Laboratory Science

Log in or Register to get access to full text downloads.

Remember me or Register

DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Effect of Exposure to Rifampicin on Multi-Resistant Bacterial Isolates from Diabetic and Non-Diabetic Wounds

ON Esebelahie, R Omoregie, UE Airughiomon, IN Ibeh, RM Mordi, HO Ogefere, SJ Utsalo


The plasmid curing effect of rifampicin on multi-drug resistant bacterial isolates from diabetic and non-diabetic wounds was investigated. The isolates were resistant to gentamicin, ciprofloxacin and ofloxacin, with minimum
inhibitory concentrations of > 80μg/ml. The result with isolates from diabetic wounds revealed that Staphylococcus aureus, Enterococcus faecalis and Klebsiella pneumoniae showed high rates of cure (range; 75 – 100%) after rifampicin exposure, while Proteus mirabilis and Pseudomonas aeruginosa showed low cure rates (range; 0 – 20%). One strain each of Staphylococcus aureus and Pseudomonas aeruginosa from non-diabetic wounds showed a high rate of cure (range; 5 – 100%), while the cure rates for other isolates ranged from 0 – 35%. Conclusively, a combination of rifampicin and other antibacterials may be effective in the management of wound infections due to bacteria carrying rifampicin curable multi-drug resistance plasmid(s).
AJOL African Journals Online