Journal of Pharmaceutical and Allied Sciences

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Comparative phytochemical and growth inhibitory studies on the leaf and root bark extracts of securinega Virosa (roxb ex. Willd) baill (euphoriaceae)

E O Ikpefan, B A Ayinde, J.O Ikpefan


Securinega virosa is one of the plants used in South-western part of Nigeria in treating cancer. This claim was evaluated using the guinea corn radicle length inhibition assay for anti-proliferation. The growth inhibitory tests were carried out between 1-30 mg/ in a period of 24-96 h while the phytochemical screening was carried out on the plant parts using standard methods. At 24 h, the control seeds had an average radicle length of 2.33 ± 0.63 mm while seeds treated with 20 and 30 mg/ml of extract showed 0.23 ± 0.11 (mm) and 100% growth inhibition respectively. At 96 h, an average length of 0.53 ± 0.25 mm (99 % inhibition) was observed for the leaf extract at 20 mg/ml and 100 % growth inhibition for seeds treated with 30 mg/ml. The root bark extract on the other hand, showed 96.09 and 99.34 % growth reductions, respectively at 20 mg/ml and 30 mg/ml concentrations. The results show a significant growth inhibitory effect of the plant extracts, particularly the leaf extract, hence can be considered in preparing recipes for tumor-related ailments. Further work, especially chromatographic analysis leading to isolation and the use of appropriate human cell lines are needed to support this.

 Keywords: Securinega virosa, antiproliferation, Sorghum bicolor, Phytochemicals, Radicle

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