Amoxicillin loaded-sorbitan monostearate–alginate microparticles as mucoadhesive delivery system for anti-microbial therapy

Abstract

Antimicrobial resistance has been a challenge to effective antibiotic delivery. Highly technical approaches that meet therapeutic needs are being studied to improve drug bioavailability. This present work seeks to formulate and characterize amoxicillin - loaded sorbitan monostearate-sodium alginate microparticles as mucoadhesive drug delivery for antimicrobial therapy. Three optimized batches of mucoadhesive sorbitan monostearate-alginate microparticles were characterized for particle size, polydispersity index, encapsulation efficiency, viscosity, and mucoadhesivity. Sensitivity test, FTIR spectroscopy and in-vitro drug release were also performed. The particle sizes were between 457 and 872.3 nm. The mean polydispersity index was about 0.569. The encapsulation efficiencies were above 65 %. The pH, viscosity, shear stress and mucoadhesivity were high and decreased gradually with time. The FTIR showed stability and correlation between the formulations and materials used. Sensitivity test showed high susceptibility between 29.00 and 49.33 mm. The drug release followed mostly first order kinetics with R² > 0.9. Mucoadhesive sorbitan monostearatealginate polymer can be explored as a novel construct for better delivery of amoxicillin.

Keywords: sorbitan monostearate, sodium alginate, mucoadhesion, bioavailability, amoxicillin