Synthesis and anti-inflammatory activity of e-3-Arylidene flavanones synthesized by simple base catalysed condensation of appropriate Aryl Aldehydes and 2’4’-Dihydroxy Acetophenone

  • J Lincy
  • G Mathew
  • N Gopal
Keywords: E-3Arylidene flavanone, 2’, 4’-dihydroxy acetophenone, One pot method, anti-inflammatory activity, natural flavanone.

Abstract

A set of six E-3Arylidene flavanones were synthesized by simple base catalysed condensation of appropriate aryl aldehydes and 2’4’-dihydroxy acetophenone. Screening of the anti-inflammatory activity was by carageenan induced paw edema method.Only four of the synthesized flavanones were found to exhibit antiinflammatory action. Due to structural similarity with those of natural flavanones, all the synthesized compounds were expected to exhibit
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eISSN: 1596-8499