The chemistry and biology of the anticancer agent, taxol: A review
Keywords: anti cancer agents, Taxol, Taxus brevifolia, mechanism of action, combretastatins, Sorafenib
AbstractTaxol, is conceivably the single most essential anticancer drug, today. It was first isolated in exceptionally low yield from the bark of the Western Yew, Taxus brevifolia. The clinical effectiveness of Taxol has impelled an incredible endeavor to obtain this intricate molecule synthetically. Owing to the chemical complication of Taxol, its commercial manufacture by
total synthesis is not likely to be economical. The chemical and biological properties, along with mechanism of action of Taxol are discussed here.
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