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Transdermal delivery systems are forms of drug delivery involving the dermis, as distinct from topical, oral or other forms of parenteral dosage forms. Over the years transdermal drug delivery systems have progressed in terms of usage and innovations making it gain increasing popularity. The route has a lot of advantages over other dosage forms. New innovations are being consistently introduced in transdermal drug delivery systems. Among these are the delivery of drugs using peptide chaperones, technologies to reduce the skins resistance to administered drugs, discovery of transdermal penetration enhances and low frequency ultrasound treatment of skin to enhance drug penetration.