Phytochemical screening, proximate analysis and acute toxicity studies of leaves of Cola lepidota k. Schum (sterculiaceae)

Abstract

Phytochemical screening, proximate analysis and acute toxicity studies were carried out on the leaf extract of Cola lepidota, in accordance with established standard procedures. The proximate analysis reveals a moisture content of 27.43 ± 3.11 % w/w, total ash value 9.32 ± 0.27 % w/w, acid insoluble ash 3.12 ± 1.05 % w/w, water soluble ash 3.95 ± 2.17 % w/w, alcohol extractive
value 0.47 ± 0.23 % w/w, and water extractive 2.04 ± 0.13 % w/w. Phytochemical screening results indicate the presence of saponins, flavonoids, phytosterols and phenols. Acute toxicity study showed there was no mortality at 8000 mg/kg of the extract. The results indicate that the plant is rich in phytochemicals and is relatively safe.

Key words: Phytochemicals, acute toxicity, proximate analysis, phytochemical screening