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Journal of Pharmaceutical and Allied Sciences

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Phytochemical screening, proximate analysis and acute toxicity studies of leaves of Cola lepidota k. Schum (sterculiaceae)

V Imieje, I Igbe, A Falodun

Abstract


Phytochemical screening, proximate analysis and acute toxicity studies were carried out on the leaf extract of Cola lepidota, in accordance with established standard procedures. The proximate analysis reveals a moisture content of 27.43 ± 3.11 % w/w, total ash value 9.32 ± 0.27 % w/w, acid insoluble ash 3.12 ± 1.05 % w/w, water soluble ash 3.95 ± 2.17 % w/w, alcohol extractive
value 0.47 ± 0.23 % w/w, and water extractive 2.04 ± 0.13 % w/w. Phytochemical screening results indicate the presence of saponins, flavonoids, phytosterols and phenols. Acute toxicity study showed there was no mortality at 8000 mg/kg of the extract. The results indicate that the plant is rich in phytochemicals and is relatively safe.

Key words: Phytochemicals, acute toxicity, proximate analysis, phytochemical screening




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