The paper discussed the environmental challenges in the Niger-Delta region of Nigeria with emphasis on the impacts on agricultural production. It thus discussed the concepts of Niger-Delta, Environmental pollution, Niger-Delta crises and Agriculture. The paper posits that there are positive relationships between these concepts justified on the basis of socio-Economic, political, health and agricultural under-development. The paper hence sees a looming bleak and dead-end to agricultural production and food security in Niger-Delta. Based on these theoretical positions, it recommends for active and pro-active measures to the environmental challenges in Niger-Delta region of Nigeria.