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DOI:
10.4314/jpb.v7i2.4Keywords:
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Main Article Content
(+) Aeroplysinin-1: antibacterial and cytotoxic principle from the sponge Pseudoceratina (Aiolocroia) crassa
Abstract
Bioactivity- guided fractionation of methylene chloride, ethyl acetate fractions of the sponge Pseudoceratina (Aiolocroia) crassa has led to the isolation and characterisation of (+)-aeroplysinin-1 as the bioactive principle. The structure of the compound was determined by spectroscopic methods. (+)-Aeroplysinin-1 showed broad spectrum activity against a number of aerobic bacteria, Gram-positive and Gram-negative anaerobes, L1210, P 388 cells, weakly cytotoxic against KB cells in addition to the reported antibacterial activity.
Keywords: Bioactivity-guided isolation; (+) Aeroplysinin-1, Antibacterial; Cytotoxic
