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Published:
Jul 15, 2013DOI:
10.4314/jpb.v9i2.3Keywords:
Article Details
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Main Article Content
Quality assessment of ten brands of loperamide hydrochloride marketed in Maiduguri Metropolitan Council (MMC)
Abstract
The experiment involves analysis of ten (10) samples of loperamide hydrochloride capsules using HPLC and UV spectrophotometry. The samples were dissolved in dilute hydrochloric acid and acetonitrile; absorbance and wavelength determined and compared with that of the standard. Wavelength of the maximum absorbance in the range of 226nm-260nm was used. From the result obtained in the UV Spectrophotometry, sample A (Diarrachur), sample C (Chibueze) sample D (Zukcure), sample G (AGS) all passed the stated standard required because they had percentage content in the range of 95-105%. Samples that failed included Sample B (Darriatus), Sample E (Diatex), Sample F (Diarecure), Sample H (Seloped), Sample I (Himadium) and Sample J (Imodium) because they gave values either above or below the acceptable range of 95-105%. Percentage content for each sample was determined using their various peak areas to calculate the actual content.
Keywords: Loperamide hydrochloride, HPLC, UV Spectroscopy
