Evaluation of the antidiarrhoeal activity of the aqueous leaf extract of Dialium guineense in mice
Diarrhoea has been recognized as being responsible for high mortality rate among the population especially in infants. Many cases of diarrhoea are fortunately, acute in nature and respond well to a number of well tried remedies including traditional remedies. The leaves of Dialium guineense have been used traditionally in the treatment of diarrhoea. The aim of this study was to evaluate the antidiarrhoeal activity of D. guineense leaf extract in mice using different experimental model. The results showed that the aqueous leaf extract of D. guineense caused a significant (P< 0.001) reduction in the number of stools and frequency of diarrhoea in castor oil induced diarrhoea in mice. The extract produced significant (P< 0.01) inhibition of intestinal transit with the dose of 400 mg/kg having the highest effect. The extract also produced a dose dependent and significant (P< 0.01) reduction in volume and weight of fluid accumulated in the GIT compared to the control. It was thus concluded that the aqueous leaf extract of D. guineense possesses significant anti-diarrhoeal activity probably due to its effect of decreasing GIT motility and fluid accumulation.
Keywords: Diarrhoea; Rats; Mice; Dialium guineense, Castor oil