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Published:
Jun 14, 2018DOI:
10.4314/jpb.v14i2.7Keywords:
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Main Article Content
Antimicrobial activity of ipolamiide isolated from the stembark of <i>Stereospermum kunthianum</i> Cham (Bignoniaceae)
Abstract
Stereospermum kunthianum (Bignoniaceae) plant is used in traditional ethnomedicine in treating bronchitis, venereal diseases, diarrhoea and dysentery. It is also used in the treatment of ulcers, leprosy, skin eruptions, respiratory ailments and gastritis. In continuation of our study of the activity of Stereospermum kunthianum, we subjected the compound ipolamiide, previously isolated and characterized, to antimicrobial study. The antimicrobial activity of ipolamiide was studied using agar cup plate and broth dilution methods against the following clinical isolates; Escherichia coli, Staphylococcus aureus, Methicillin resistant Staphylococcus aureus, Shigella dysenteriae, Klebsiella pneumoniae, Candida albicans, Candida krusei, Candida tropicalis and Pseudomonas aeruginosa. The results of antimicrobial screening showed that all the organisms tested were susceptible to ipolamiide and was found to be active against Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, Salmonella typhi for the bacteria and Candida krusei for the fungi. It was found to be inactive against Methicillin resistant Staphylococcus aureus (MRSA), Shigella dysenteriae and Candida albicans and Candida tropicalis. The compound showed zone of inhibition ranging from 21–29mm against all the tested microorganisms except MRSA and Shigella dysenteriae, standard antibiotic drugs erythromycin and fluconazole at concentrations of 5μg/ml each showed zones of inhibition ranging from 32 – 41mm for erythromycin except the Candidas while Fluconazole showed zones of inhibition ranging from 32 – 35mm for the Candidas.
Keywords: Stereospermum kunthianum; Antibacterial activity; Paper disc diffusion; Phytochemical screening
