Toxicological evaluation of the ethanol extract of Lophira alata (Ochnaceae) stem bark in rats
Abstract
Though Lophira alata is used in ethnomedicine for the management of a host of central nervous and systemic diseases, the toxicity profile has not been investigated. This study evaluated the toxicological profile of the ethanol extract of Lophira alata stem bark in rats. The mean lethal dose was determined. Animals were treated with 50-800 mg/kg of the ethanol extract for four weeks after which body weight/organ ratio, haematological, biochemical (renal and hepatic) and lipid profile of test animals were evaluated. Changes in body weight and histopathological examination of brains, kidneys and livers were also carried out. Lower doses (50-400 mg/kg) did not affect body weight, organ/body weight ratio, hepatic, renal, haematological, lipid profile and morphology of organs of test animals. The highest dose affected creatinine levels, serum proteins and induced some histopathological changes. Lophira alata is relatively safe at low doses but high doses of Lophira alata should be used with caution.
Keywords: Lophira alata; Toxicity; Lipd profile; Haematological indices
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
