Article Sidebar
Keywords:
DTES Hypermotility Phenytoin Cabamazepine Sodium valproate Wistar rats
Article Details
Issue
Section
Articles
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Diffuse Transcranial Electrical Stimulation (DTES)-induced hypermotility and convulsion: A model for screening drugs with anti-convulsant properties
Abstract
Status epilepticus (SE) was induced in male and female Wistar rats by passing low direct current across the brain via steel electrodes clipped to their ear lobes, and the effects of some anti-convulsants on these animals were studied in a motility counter chamber. Sodium valproate was found to significantly attenuate diffuse transcranial electrical stimulation (DTES)-induced hypermotility and protected the animals against DTES-induced convulsions. Higher voltages were needed to induce convulsion in rats pretreated with sodium valproate. Hypermotility induced by DTES was attenuated by carbamazepine, an anti- convulsant. It was also observed that carbamazepine abolished DTES-induced convulsion and higher voltages were needed to induce convulsion in rats pretreated with carbamazepine. Phenytoin inhibited DTES induced convulsion and attenuated DTES-induced hypermotility in Wistar rats. Higher voltages were needed to induce convulsion in pretreated animals than in normal animals. It is therefore suggestive that DTES-induced hypermotility can be used as an animal model for testing drugs that can be of advantage in the management of non convulsive (petit mal) status epilepticus (SE), and DTES induced convulsion as a model for testing drugs with anticonvulsant properties.
Key Words: DTES; Hypermotility; Phenytoin; Cabamazepine; Sodium valproate; Wistar rats.
Journal of Pharmacy and Bioresources Vol.1(1) 2004: 70-75
Key Words: DTES; Hypermotility; Phenytoin; Cabamazepine; Sodium valproate; Wistar rats.
Journal of Pharmacy and Bioresources Vol.1(1) 2004: 70-75
