Diffuse Transcranial Electrical Stimulation (DTES)-induced hypermotility and convulsion: A model for screening drugs with anti-convulsant properties

  • Sunday O Otimenyin Department of Pharmacology, Faculty of Pharmaceutical sciences, University of Jos, Jos. Nigeria
  • Uche A Osunkwo Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto. Nigeri
Keywords: DTES, Hypermotility, Phenytoin, Cabamazepine, Sodium valproate, Wistar rats

Abstract

Status epilepticus (SE) was induced in male and female Wistar rats by passing low direct current across the brain via steel electrodes clipped to their ear lobes, and the effects of some anti-convulsants on these animals were studied in a motility counter chamber. Sodium valproate was found to significantly attenuate diffuse transcranial electrical stimulation (DTES)-induced hypermotility and protected the animals against DTES-induced convulsions. Higher voltages were needed to induce convulsion in rats pretreated with sodium valproate. Hypermotility induced by DTES was attenuated by carbamazepine, an anti- convulsant. It was also observed that carbamazepine abolished DTES-induced convulsion and higher voltages were needed to induce convulsion in rats pretreated with carbamazepine. Phenytoin inhibited DTES induced convulsion and attenuated DTES-induced hypermotility in Wistar rats. Higher voltages were needed to induce convulsion in pretreated animals than in normal animals. It is therefore suggestive that DTES-induced hypermotility can be used as an animal model for testing drugs that can be of advantage in the management of non convulsive (petit mal) status epilepticus (SE), and DTES induced convulsion as a model for testing drugs with anticonvulsant properties.
Key Words: DTES; Hypermotility; Phenytoin; Cabamazepine; Sodium valproate; Wistar rats.
Journal of Pharmacy and Bioresources Vol.1(1) 2004: 70-75
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