Quality assessment of some brands of Ciprofloxacin tablets on sale in Abuja, Nigeria

  • Philip F Builders Department of Pharmaceutical Technology and Raw Material Development
  • Ayo Egeiyeh Department of Pharmaceutical Technology and Raw Material Development
  • Peters Oladosu Department of Microbiology and Human Virology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu, P.M.B. 21 Garki, Abuja. Nigeria.
  • Olubayo O Kunle Department of Pharmaceutical Technology and Raw Material Development
Keywords: Ciprofloxacin, Quality assessment, Spectrophotometric evaluation, Microbial potency

Abstract

The quality of the various brands of ciprofloxacin tablets in circulation within Abuja, the Federal Capital City of Nigeria, was assessed. Spectrophotometric evaluation showed that all the brands contained a chemical equivalent of ciprofloxacin within the limits of the official specification. However their antimicrobial activity as indicated by the zone of inhibition was less than that of the reference standard. Three of the ten samples tested failed the disintegration and dissolution tests as specified by the British Pharmacopoeia for film coated tablets.

Key words: Ciprofloxacin; Quality assessment; Spectrophotometric evaluation; Microbial potency
Journal of Pharmacy and Bioresources Vol. 2 (1) 2004: 49-54
Published
2005-10-12
Section
Articles

eISSN: 0189-8442