Effects of aqueous crude extract of Securidaca longipedunculata on the uteri and ilea of rats and rabbits

  • J A Anuka
  • S J Alawode
  • A H Yaro
  • N N Wannang
  • E B Ezenwanne
Keywords: <i>Securidaca longipedunculata</i>, Uterus, Ileum, Oxytocin-induced contractions

Abstract



The aqueous extracts of Securidaca longipedunculata were investigated in vitro and in vivo in rats and rabbits. This study compares primarily the pharmacological actions of the root, stem and leaf extracts. The aqueous extracts (leaves, stem and root) of Securidaca longipedunculata were found to produce dose dependent contractions of the smooth muscles of the rat and rabbit uteri and ilea. The root extract produced the greatest response compared with the leaves or stem extract; hence, its use for the rest of the work. The root extract enhanced oxytocin-induced contractions of uteri smooth muscles. The oxytocin-like effect of the extract is consistent with the use of the extract locally to induce abortion. It was observed that the pregnant uteri (rat and rabbit) were more responsive than the rat uterus. Concentrations ranging from 0.1 mg/ml to 1.6 mg/ml were tried in this work. At a dose of 10mg/ml the root extract produced no effect in few regular cycling rats while the same dose induced irregular cycles (cyclic disturbances) in most of the rats that had regular cycles. The cyclic disturbances induced by the root extract coupled with its oxytocin-like effect limit its use in pregnancy as it may cause abortifacient effect.

Keywords: Securidaca longipedunculata; Uterus; Ileum; Oxytocin-induced contractions

Journal of Pharmacy and Bioresources Vol. 3 (2) 2006: pp. 116-121
Published
2007-08-06
Section
Articles

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eISSN: 0189-8442