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Keywords:
Spondias mombin Senna alata Hypolipidemic effect Hypoglycaemic effect
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Main Article Content
Effects of <i>Spondias mombin</i> stem bark and <i>Senna alata</i> leaf extracts on some biochemical parameters in rats
Abstract
Spondias mombin stem bark and Senna alata leaf ethanolic extracts, reputed for management of diabetes by traditional medicine practitioners, were investigated for effects on certain biochemical parameters in healthy rats at
150 mg/kg and 400 mg/kg for 28 days. Both plants significantly (P<0.05) lowered all lipid indices such as low density lipoprotein cholesterol, total cholesterol and triglycerides, but increased HDL-cholesterol level in treated
rats. Hypoglycaemic effects of both extracts were comparable and peaked by the 4th week. PCV also increased significantly (P<0.05) following Spondias mombin administration in 4 weeks, and decreased with Senna alata.
Weights of treated animals increased significantly (P<0.05) with 150 mg/kg of both extracts up to the 2nd week. This study suggests relevance of Spondias mombin and Senna alata in folkloric treatment of hyperglycaemia and
associated conditions. Both plant extracts produced toxicity only in the kidney and heart of treated rats.
150 mg/kg and 400 mg/kg for 28 days. Both plants significantly (P<0.05) lowered all lipid indices such as low density lipoprotein cholesterol, total cholesterol and triglycerides, but increased HDL-cholesterol level in treated
rats. Hypoglycaemic effects of both extracts were comparable and peaked by the 4th week. PCV also increased significantly (P<0.05) following Spondias mombin administration in 4 weeks, and decreased with Senna alata.
Weights of treated animals increased significantly (P<0.05) with 150 mg/kg of both extracts up to the 2nd week. This study suggests relevance of Spondias mombin and Senna alata in folkloric treatment of hyperglycaemia and
associated conditions. Both plant extracts produced toxicity only in the kidney and heart of treated rats.
