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Journal of Pharmacy & Bioresources

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Bioactive compounds from the alga Dictyopteris undulata

MES Koker

Abstract


An investigation of biologically active compounds from the alga Dictyopteris undulata by bioassay-guided fractionation has led to the isolation and identification of zonarol, chromazonarol, zonaroic acid and the hitherto unreported isozonaroic acid. Their structures were determined by chemical transformation, GC and GC- MS comparison of transformed intermediates and by spectroscopic means. X-ray crystallography of zonarol confirmed the gross structure of this compound and also gave the relative stereochemistry at C- 9 and C- 10 as trans. All of these compounds were found to exhibit antimicrobial activity. Some also showed activity against L1210 cells and antiviral activity.

Keywords: Bioactivity-guided isolation; Antimicrobial; Antiviral; L1210 cells




http://dx.doi.org/10.4314/jpb.v7i2.6
AJOL African Journals Online