Anti-inflammatory activity of chromatographic fractions of Stereospermum kunthianum Cham Sandrine Petit (Bignoniaceae) stem

  • FP Ching
  • EKI Omogbai
Keywords: Anti-inflammatory activity, Chromatographic fractions, Stereospermum kunthianum.

Abstract

The study evaluates the anti-inflammatory activity of the vacuum liquid (A, B and C) and column (L, S and Y) chromatographic fractions of Stereospermum kunthianum stem bark. The fractions at the doses of 100, 200 and 400 mg/kg were evaluated using the carrageenan-induced paw oedema model in rats. The control rats received normal saline (5 ml/kg) while indomethacin (10 mg/kg) served as the reference drug. Fractions A, B and C dose-dependently and significantly (P<0.05) reduced the paw swelling (oedema) in the treated animals compared to the control animals. The maximum reduction in paw swelling was at the third hour post carrageenan injection. Indomethacin (10 mg/kg) caused a more reduction in the paw swelling compared to the fractions. Similarly, the column chromatographic fractions L, S and Y dose-dependently and significantly (P<0.05) caused a reduction in the paw swelling. The results indicate that the fractions may inhibit inflammatory responses mediated by prostaglandins and other inflammatory mediators.

Keywords: Anti-inflammatory activity, Chromatographic fractions, Stereospermum kunthianum.

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Articles

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eISSN: 0189-8442