Antithrombotic activities of methanolic extract of Garcinia kola in rats

  • SC Ohadoma
  • I Nnatuanya
  • PJC Nwosu
  • JC Enye
  • O Nnaeto
Keywords: Garcinia kola, Antithrombotic activity, Rats.

Abstract

The antithrombotic activities of methanolic extract of Garcinia kola was investigated in rats. Haematological parameters including bleeding time, whole blood clotting time, and platelets count were employed in this analysis. The rats were divided into four (4) groups (A-D). 0.5ml/day of normal saline was administered orally to group A rats serving as negative control group, 250Mg/kg/day of aspirin was administered orally to group B rats. Group C and D rats received 250mg/kg/day and 500mg/kg/day of the extract respectively, which lasted for two weeks before the haematological analysis. The results indicated that group A rats had a mean value of 4.20, 2.06, and 349 for bleeding time, whole blood clotting time, and platelets count respectively. Rats in group B were taken as positive control and showed mean value of 7.05, 2.04, and 64 for bleeding time, whole blood clotting and platelets count respectively. Group C and D indicated mean values of 6.12, 2.24, 88 and 7.67, 2.29, 80 respectively for bleeding time, whole blood clotting, and platelets count. This study indicates that the methanolic extract of Garcinia kola definitely exhibits an antithrombotic activity that is dose-dependent.

Keywords: Garcinia kola, Antithrombotic activity; Rats.

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eISSN: 0189-8442