Article Sidebar
DOI:
10.4314/jpb.v8i2.3Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Effects of standardized methanol extract of <i>Andrographis paniculata</i> on guinea pig tracheal cyclooxygenase and rat paw inflammation
Abstract
Extracts of Andrographis paniculata Nees is used in traditional medicine for the treatment several diseases including inflammation, asthma and common cold. The aim of this study was to investigate the possible effects of a clinical dose of the methanol extract of A. paniculata (AP) on tracheal cyclooxygenase and inflammation in animals. Ovalbumin (OA) sensitized guinea pigs were orally treated daily for 21 consecutive days with water, 2.86 mg/kg AP, or 10 mg/kg prednisolone. At the end of treatment tracheae were excised and assayed for cyclooxygenase enzyme. The same dose of AP was tested on acute inflammation in rat using 10 mg/kg indomethacin as the positive control. Although 2.86 mg/kg of AP did not significantly reduce guinea pig tracheal cyclooxygenase activity when compared with control it significantly (P < 0.05) reduced rat paw size within the first hour of induction of inflammation. The clinical dose of AP used for the study possesses anti-inflammatory property but higher doses may be more effective in the inhibition of airway cyclooxygenase.
Keywords: Andrographis paniculata; Methanol extract; Asthma; Inflammation; Cyclooxygenase
