Investigating the Relationship between Diabetes and Alzheimer’s Disease:
A Network Systems Biology Approach
Ageing is associated with a number of diseases. Alzheimer’s disease (AD) and diabetes are among such most common diseases. These two diseases are considered to be fundamentally similar disorders because they share some common elements, though they differ in the time of onset, tissues affected as well as the magnitudes of their specific traits. The present study was undertaken to prospect the association between the genes involved in Diabetes and AD; and their common pathophysiology. Using a network system biology approach, the genes common between Diabetes and AD were retrieved from DisGeNET database. The common genes were analysed using in silico tool, Cyctoscape’s various plug-ins, ClusterONE, CytoHubba, ClueGO and CluePedia. Eleven genes which can act as potential marker for both Diabetes and AD namely IL4, ICAM1, ALB, INS, CSF2, IL6, TNF, IL10, GAPDH, TLR4, and AKT have been identified in the present study. This is the first study of its kind in which relationship between Diabetes and AD has been investigated to identify their common genes, which can help in better understanding of pathophysiology of these age-related diseases.
© 2017 Uganda Martyrs University. All rights reserved.
The JSSD and the individual contributions contained therein are protected under copyright by Uganda Martyrs University and the following terms and conditions apply to their use:
Photocopying: Single photocopies of single articles may be made for personal use as allowed under the Copyright Act. Permission of the copyright owner and payment of a fee is required for other photocopying, including multiple copying, copying for advertising/promotional purposes, resale and all forms of document delivery. Special rates are available for educational institutions that wish to make copies for non-profit educational use. Permissions may be sought directly from Uganda Martyrs University (P. O. Box 5498 Kampala, Uganda; Tel.: +256414690021; e-mail: firstname.lastname@example.org; Fax: +256 (0) 382 410100).
Derivative works: Subscribers may reproduce tables of contents or prepare lists of articles and abstracts for circulation within their institutions but the permission of the copyright owner is required for resale or distribution outside the institution. Permission of the copyright owner is required for all other derivative works including compilations and translations.
Electronic storage and usage: Permission of the copyright owner is required to store and use electronically any material contained in the JSSD, including any article or part of an article. Except as outlined above, no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the copyright owner.
Disclaimer: Uganda Martyrs University and the Board of the JSSD make every effort to ensure the accuracy of the information contained in the Journal. However, the University makes no representations or warranties whatsoever as to the accuracy, completeness or suitability for any purpose of the content and disclaim all such representations and warranties whether express or implied to the maximum extent permitted by law. Any views expressed in this publication are the views of the authors and are not necessarily the views of the editors, Uganda Martyrs University, the School of Postgraduate Studies and Research or their partners.
Creative commons license: This journal content is publsihed under a CC-BY-NC license.