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Libyan Journal of Medicine

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Antinociceptive activity of Mentha piperita leaf aqueous extract in mice

YA Taher

Abstract


Background: Mentha piperita L. (Labiatae) is an herbaceous plant, used in folk medicine for the treatment of several medical disorders.
Methods and Results: In the present study, the aqueous extract of Mentha piperita leaf, at the i.p doses 200 and 400 mg/kg, showed significant analgesic effects against both acetic acid-induced writhing and hot plateinduced thermal stimulation in mice, with protection values of 51.79% and 20.21% respectively. On the contrary, the Mentha piperita leaf aqueous extract did not exhibit anti-inflammatory activity against carrageenan induced paw oedema.
Conclusion: These findings indicate that Mentha piperita has a potential analgesic effect that may possibly have mediated centrally and peripherally, as well as providing a pharmacological evidence for its traditional use as a pain reliever.

Keywords: Mentha piperita; traditional medicine; analgesic activity; mice




http://dx.doi.org/10.3402/ljm.v7i0.16205
AJOL African Journals Online