This study aimed at examining the impact of digitization in the teaching and learning of Chemistry and Mathematics in open and distance learning (ODL) at the Distance Learning Institute of the University of Lagos. A sample of 122 Chemistry and Mathematics students and lecturers was selected using simple random sampling. Data was collected using a questionnaire and analysed using descriptive statistics and Chi-Square. The findings were that the respondents lacked adequate digitization facilities and exposure. Their utilisation of digital facilities was characterized as low. It is recommended that the Institute makes digitization a matter of ultimate priority and provides funds for staff and student training.