Efficacy of Praziquantel in treating Schistosoma mansoni infected School children in Tumuga and Waja, north Ethiopia

  • T Dejenie
  • T Asmelash
  • M Abdelkadir

Abstract

Praziquantel (PZQ) is a drug of choice for treating schistosomiasis mansoni. Praziquantel was effectively used to treat schistosomiasis, but there are reports that indicate the appearance of Praziquantel resistance. The objective of this study was to determine the rate of S. mansoni infection before and after single treatment, thus to measure the efficacy of Praziquantel in treating Schistosoma mansoni infected individuals in the study area. The study utilized microscopic examination of two Kato–Katz slides for each individual sample before and after treatment. The cure rate of S. mansoni infection by Praziquantel in the two study areas remains high and with no significant difference. In Timuga cure rate was 93.44% and in Waja 88.99% (?2= 3.644 and P= 0.16). Efficacy of Praziquantel in treating infections due to S. mansoni is still high and there is no evidence for resistance S. mansoni against Praziquantel in Tumuga and Waja. Key words: Efficacy, Praziquantel, Schistosomiasis, School children.
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eISSN: 2220-184X
print ISSN: 2073-073X