Pharmacokinetics of a single intravenous injection of cefquinome in rabbits

Abstract

The current study was carried out to investigate the pharmacokinetic profile of cefquinome following a single IV injection in ten New Zealand white rabbits (2-2.5 kg body weight). Cefquinome was injected intravenously (2mg/kg body weight) and blood samples were collected before drug administration and up to 24h after injection. Cefquinome plasma concentrations were measured using HPLC (high- performance liquid chromatography). The result showed that the plasma concentration of cefquinome was 9.13 ± 0.43 μg/mL at 5min post injection then declined gradually to 0.73 ± 0.18μg/mL after 2 hours. No cefquinome concentration could be detected at 4h post injection. The major pharmacokinetic parameters (Mean ± SEM) were T1/2 λz 0.52 ± 0.05h, AUC0-∞ 9.13 ± 0.63 h*μg/mL, Cl 239.25 ±14.61 mL/h/kg, Vz 170.89 ± 9.7 mL/kg and MRT0-∞ 0.75 ±0.06 h.