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Mar 30, 2024Keywords:
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Main Article Content
Impact of Newbouldia laevis Root Extract on Liver Enzymes in Rats
Abstract
This twenty-eight-day experimental study aimed to investigate the impact of Newbouldia laevis root extract on liver enzymes in rats. Sixteen male Wistar rats were randomly divided into four groups, each consisting of four rats. The first group, designated as the control, received only feed and water. Meanwhile, groups two, three, and four were administered the plant extract at doses of 200, 400, and 600 mg/kg, respectively. To assess the potential effects of the extract on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels in rat serum were analyzed using the standard method. The AST level was significantly (p<0.05) lower in the group that received 200 mg/kg of extract than in the group that received 600 mg/kg of extract. Additionally, after 28 days, the control group's AST levels were still considerably (p<0.05) lower than those of the groups that received the extract. The ALT results at 14 and 28 days following the administration of the extracts did not significantly differ across the groups when compared to each other. Following 28 days of treatment, the 400 mg/kg extract group had much higher ALP levels (p<0.05), but there was no significant difference (p>0.05) between any of the other groups. The findings contribute valuable insights into the possible biochemical effect of N. laevis extract.
