Experimental Infections Of Domestic Rabbits (<i>Oryctolagus cuniculus</I>) With <i>Trypanosoma brucei</i> And <i>Trypanosoma congolense</i>: A Comparative Study

Abstract

Comparative study of single infections of domestic rabbits (Oryctolagus cuniculus) with Nigerian isolates of Trypanosoma brucei (Gboko strain), and Trypanosoma congolense (Binchi strain) was carried out in the laboratory for clinical and haematological effects. Eighteen rabbits of 10-14 weeks old weighing between 600-1200 grams were used for the study. The rabbits of both sexes were randomly selected and divided into groups. The level of infection was studied by determining total red blood cell (RBC) count, haemoglobin estimation, total and differential white blood cell (WBC) count, changes in body weight, mortality, rectal temperature changes and other clinical signs of trypanosomiasis. There was significant reduction (P<0.001) in the total red blood cell counts and haemoglobin level in the infected rabbits when compared to the control rabbits with the effect of being more pronounced in rabbits infected with T. congolense. Both parasites produced similar clinical symptoms which included weight loss, unthriftiness, anorexia, fever, paleness of mucous membrane, and oedema of the facial region. One death was recorded in each of the infected group. Possible reasons for the significant differences in the total red blood cell count, haemoglobin level, and total white blood cell count are discussed.

Keywords: Single infections, T. brucei, T. congolense, rabbits, comparative