Effect of Oral Administration of “Gadagi” Tea on Lipid Profile in Rats

Abstract

Effect of oral administration of “Gadagi” tea on lipid profile was assessed in 50 healthy male albino rats which were grouped and administered with different doses(mg/kg) i.e low dose (380mg/kg, 415mg/kg, 365mg/kg,
315mg/kg for “sak”, ”sada” and “magani” respectively), standard dose (760mg/kg, 830mg/kg, 730mg/kg for “sak’, ”sada” and “magani” respectively) and high dose ( 1500mg/kg, 1700mg/kg and 1460mg/kg for “sak’’, ”sada” and “magani” groups respectively) for a period of four weeks. Animals that were not administered with the tea constituted
the control group. At the end of fourth week, the animals were sacrificed and their serum Total Cholesterol (T. Chol), HDL–Cholesterol (HDL Chol), Triglyceride (TRIG), very low – density lipoproteins (VLDL) and Low Density
Lipoproteins (LDL) levels were determined. Although no significant difference(P<0.05) was found between the experimental groups and the control group using analysis of variance (ANOVA), mean serum LDL, T. Chol and TRIG levels were slightly lower in rats orally administered with “magani” at standard dose level than that of the control rats. Thus, it could be suggested that “magani” especially at standard dose could reduce some of the risk factors of cardiovascular disease.

Keywords: “Gadagi” tea, Lipid profile, Cholesterol.