Lupus Anticoagulatiuon African Women With Recurrent Abortions

  • OA Awodu Department of Haematology, School of Medicine, University of Benin, Benin City
  • OA Ejeele Department of Haematology, University of Port- Harcourt Teaching Hospital, Port- Harcourt,
  • WA Shokunbi Department of Haematology, University Hospital, Ibadan
  • AA Famodu Department of Haematology, School of Medicine, University of Benin, Benin City
Keywords: Recurrent Abortions, Pregnant Women, Lupus Anticoagulant, Kaolin clotting time

Abstract

Objective: The presence of the lupus anticoagulant (LA) an auto antibody has been implicated as a marker for first trimester spontaneous abortions as well as second and third trimester foetal death in the Caucasians. There is paucity of information on LA in African women where recurrent abortion and obstetrics complications are still common. Our aim therefore is to determine the prevalence of lupus anticoagulant in Nigerian women with recurrent abortion
Subjects and methods: A total of seventy – three pregnant women were studied. Twenty three of them had history of recurrent abortions; they were compared with 50 without obstetrics complications as controls. Coagulation studies using the kaolin clotting time were carried out on their plasma sample. Mixing experiments were conducted on samples with prolonged clotting time in order to detect the presence of the lupus anticoagulant. The anticoagulant was considered present if the kaolin clotting time ratio is greater than or equal to 1.2.
Result: Nineteen {82.62%} of the patients with recurrent abortion had normal kaolin clotting time, one {4.35%} had subnormal clotting time. The kaolin clotting time ration was greater than 1.2 in one (4.35%) of the patients with recurrent abortions signifying the presence of the lupus anticoagulant. Four (8%) of the pregnant controls had subnormal kaolin clotting time, 44 (88%) had normal clotting time while 2 (4%) had prolonged clotting time. The lupus anticoagulant was present in one (2%) of the pregnant controls.
Conclusion: A 4.35% prevalence of LA among Nigerians with recurrent foetal loss may necessitate the screening of pregnant women with history of recurrent abortion for the lupus anticoagulant. We recommend that screening for lupus anticoagulant should be part of the routine investigation for women with recurrent spontaneous abortions
KEY WORDS: Recurrent Abortions, Pregnant Women, Lupus Anticoagulant, Kaolin clotting time
Nigerian Journal of Clinical Practice Vol.6(1) 2003:26-29
Published
2005-02-24
Section
Articles

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eISSN: 1119-3077