Trinuclear Ce(IV) Salen Capped Complexes with bridging 2, 4, 6-Tris (4-Carboxyphenylimino-41-Formylphenoxy)-1, 3, 5- Triazine and 2,4,6-Tris(4-Carboxybenzimino)-1,3,5-Triazine: Synthesis, Characterization and Biological Studies

  • U. S. Oruma Coordination Chemistry and Inorganic Pharmaceuticals Unit, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, 410001, Nigeria.
  • P. O. Ukoha Coordination Chemistry and Inorganic Pharmaceuticals Unit, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, 410001, Nigeria.
  • C. J. Ezeorah Coordination Chemistry and Inorganic Pharmaceuticals Unit, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, 410001, Nigeria.
Keywords: S-triazine; salen; Trinuclear Ce(IV) Complexes; Antimicrobial activity.

Abstract

Trinuclear Ce(IV) salen capped complexes of 2,4,6-tris(4-carboxyphenylimino-41-formylphenoxy)-1,3,5-triazine (H3CT) and 2,4,6-tris(4-carboxybenzimino)-1,3,5-triazine(H3MT) were synthesized. These were characterized using UV-Visible, IR, 1H and 13C NMR spectroscopies, elemental analysis and molar conductivity measurements. The spectral studies indicate that both ligands are hexadentate and coordinates to the Ce(IV) ions through the oxygen atoms of the carboxylic group. The trinuclear Ce(IV) salen capped complexes were characterized as being bridged by carboxylate anions to the Ce(IV) salen centres and displays a coordination number of eight by involving two hydroxyl groups in the coordination sphere. The in vitro antimicrobial activities of the ligands and their Ce(IV) salen capped complexes were investigated against Gram-negative bacteria: Escherichia coli (ATCC 6749) and Pseudomonas aeruginosa (ATCC 9027), Gram-positive bacteria: Staphylococcus aureus (ATCC 6538P) and Bacillus cereus (ATCC 14579), and fungi: Candida albicans and Aspergillus niger by the agar well diffusion technique. In vitro antimicrobial test indicate that the tripodal ligand, H3MT is more potent against the test micro-organisms relative to H3CT, [{Ce(OH)2(salen)}3(CT)].3H2O and [{Ce(OH)2(salen)}3(MT)].3H2O. The MIC of H3MT against Candida albicans is comparable to that of gentamycin. Amongst the Ce(IV) salen capped complexes, [{Ce(OH)2(salen)}3(MT)].3H2O is more potent.

Published
2021-04-09
Section
Articles

Journal Identifiers


eISSN: 1119-0221