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Nigerian Journal of Health and Biomedical Sciences

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The prevalence of Antithyroglobulin and Antithyroid Microsomal Autoantibodies in Euthyroid Fertile and Infertile Nigerian Women with recurrent spontaneous Abortion and Unexplained Infertility

OS Oladimeji, OA Magbagbeola, TA Adewole, OA Vanderpuye, OA Akinwande

Abstract


Plasma levels of antithyroglobulin {TG} and microsomal thyroid peroxidase {TPO} autoantibodies were determined using the ELISA methods, in 87 euthyroid women. These were made up of 44 control women which included 8{18%} nulligravidae, 18{41%} non pregnant multiparous and 18{41%}, pregnant subjects. The infertile groups were made up of 43 women which included 18{42%} with secondary infertility, 17{39%} recurrent spontaneous aborters {RSA} and 8{19%} unexplained {Primary} infertility subjects. The microsomal antithyroid peroxidase and the anti-thyroglobulin auto-antibodies, micro titer mean values, in the infertility subjects were 347.55 units/ml and 35.23 units/ml respectively. These values were higher compared with the micro titer mean values of the control subjects with 284.40 units/ml and 32.51 units/ml respectively. The Micro titer mean value levels of the microsomal antithyroid peroxidase auto-antibodies in the primary infertility group was 437.19 units/ml and in the secondary infertility group was 362.50 units/ml compared with the micro titer mean value of control groups of 284.40 units/ml at P<0.005, were significant. Likewise the micro titer mean value of the antithyroglobulin auto antibodies level in the primary infertility group which was 36.26 units/ml and in the secondary infertility group was 33.20 units/ml compared to the micro titer mean value of control groups value of 32.51 units/ml at P<0.05 were significant. The result showed that there is a high prevalence of antithyroglobulin and antithyroid microsomal autoantibodies in the infertile subjects. These antibodies could probably play active roles in infertility problems in women.

KEY WORDS: Autoimmunity, Reproduction, Infertility, Thyroid antibodies.

Nigerian Journal of Health and Biomedical Sciences Vol.3(2) 2004: 96-99



http://dx.doi.org/10.4314/njhbs.v3i2.11518
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