PHARMACOGNOSTIC AND ANTI-DIARRHOEAL STUDIES OF LEAVES OF FICUS THONNINGII

  • DN Onwkaeme Department of Pharmacognosy, Faculty of Pharmacuetical Sciences Univetsity of Jos, Jos. Nigeria
  • F Udoh Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacuetical Sciences Univetsity of Jos, Jos. Nigeria

Abstract

The leaves of Ficus thonningii Blume (Moraceae) were subjected to pharmacognostic evaluation as well as anti-diarrhoeal studies using rats. Tannins, flavonoids, saponins and anthraquinone glycosides were detected. An intestinal transist test for the charcoal meal fed to rats was conducted. The aqueous methanolic extract showed a dose-related reduction in intestinal motility. Magnesium sulphate-induced diarrhoea was not inhibited by the extract. In the castor-oil induced diarrhoea test conducted, the rats showed signs of acute toxicity, a 40% death was recorded at the highest tested dose of 1.5kg/kg. At this dose, there was no stool. In all the doses, there was an initial increase in purgation by the 2nd h of the test, but this was followed by constipation. The results supported the co-occurrence of astringent and purgative compounds in the crude drug. The toxicity of the drug suggests that it is not recommendable for clinical use as an anti-diarrhoea drug.

Nig. J. Nat Prod. And Med. Vol.4 2000: 27-29
Section
Articles

Journal Identifiers


eISSN: 1118-6267