A Review of the Effect of 5-Flurouracil on the Outcome of Trabeculectomy in Ibadan

  • AM Baiyeroju Department of Ophthalmology, University College Hospital, Ibadan
  • JN Ubah Department of Ophthalmology, University College Hospital, Ibadan
Keywords: 5-flourouracil, trabeculectomy, glaucoma, Nigerian


Aim: To retrospectively assess the outcome of trabeculectomy performed using an intraoperative sponge soaked in 5-fluorouracil (50 mg/ml).
Methods: Trabeculectomy with an intraoperative sponge soaked with 5-fluorouracil (5-FU) was performed in 21 eyes of 14 patients. The reduction in intraocular pressure (IOP), complications and variations in visual acuity were noted.
Results: The mean preoperative IOP was 31.5 ± 10.6 mmHg. The mean postoperative IOP was 7.3 ± 5.7mmHg on the second postoperative day and 17.5 ± 9.8mmHg at 3 months. Postoperative complications were mostly transient, with 33% of eyes requiring postoperative antiglaucoma therapy to reduce IOP. Visual acuity improved postoperatively in 3 eyes, worsened in 9 eyes and remained the same in 9 eyes.
Conclusion: Even though a small study, an intraoperative sponge soaked with 5-FU seems to be a safe and effective adjunct to trabeculectomy.
Key Words: 5-flourouracil, trabeculectomy, glaucoma, Nigerian
Nigerian Journal of Ophthalmology Vol.12 (1) 2004: 14-18


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eISSN: 2468-8363
print ISSN: 0189-9171